Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.

نویسندگان

  • J Willems
  • E Bruyneel
  • V Noë
  • H Slegers
  • A Zwijsen
  • R M Mège
  • M Mareel
چکیده

A synthetic HAV-containing decapeptide homologous to the amino acid sequence 44R-Q53 in rat extracellular superoxide dismutase B affects cadherin-dependent cell aggregation. Cell lines, some of them transfected, expressing different types of cadherins were tested using in vitro cell aggregation and cell dissociation assays. A concentration-dependent inhibition of aggregation by the EC-SOD-derived HAV-containing peptide was detected only in N-cadherin expressing cells. These results suggest the localisation and possible protective role of EC-SOD B for cells expressing N-cadherin.

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عنوان ژورنال:
  • FEBS letters

دوره 363 3  شماره 

صفحات  -

تاریخ انتشار 1995